Scientists Propose Novel Theory on Origin of Genetic Code
Alan Herbert, Scientific Supervisor of the HSE International Laboratory of Bioinformatics, has put forward a new explanation for one of biology's enduring mysteries—the origin of the genetic code. According to his publication in Biology Letters, the contemporary genetic code may have originated from self-organising molecular complexes known as ‘tinkers.’ The author presents this novel hypothesis based on an analysis of secondary DNA structures using the AlphaFold 3 neural network.
Z-Flipons: How Specific DNA Regions Help Regulate Gene Function
Researchers at HSE University and InsideOutBio have applied machine learning to identify the location and functions of mirror-twisted DNA structures, known as Z-flipons, in human and mouse genomes. The scientists discovered which Z-DNA regions were conserved in both species throughout evolution and demonstrated for the first time that Z-DNA accelerates the process of creating RNA copies of genes. The findings will contribute to the development of new treatments for genetic diseases. The study has been published in Scientific Reports.
HSE Researchers Use Neural Networks to Study DNA
HSE scientists have proposed a way to improve the accuracy of finding Z-DNA, or DNA regions that are twisted to the left instead of to the right. To do this, they used neural networks and a dataset of more than 30,000 experiments conducted by different laboratories around the world. Details of the study are published in Scientific Reports.